Reproduction Abstracts

Introduction: Aneuploidies in mammalian embryos usually originate from oocyte chromosome segregation errors in meiosis I and are a major genetic cause of pregnancy loss. But the mechanism remains poorly understood. We have previously shown total two-cell arrest of IVF embryos derived from superoxide dismutase 1 (SOD1)-deficient mouse oocytes under atmospheric oxygen conditions. This study was conducted to investigate effects of intrinsic oxidative stress by a SOD1 deficiency d...